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HOWELL RESEARCH GROUP DEPARTMENT
OF CHEMISTRY |
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Total Synthesis of Laureatin
Another
project exploiting the reactivity of 1,5-dioxoaspiro[3.2]hexanes is
our effort to synthesize laureatin, a metabolite isolated from the Laurencia
red algae L. nipponica. This metabolite has shown strong activity as
a mosquito larvicide. Our retrosynthetic approach is shown in Scheme
1. |
| At present, the eneyne adduct 14 has been prepared utilizing the Sonogashira coupling of a haloalkene with an alkyne. We also have prepared compound 15 from the ring opening of 1,5-dioxoaspiro[3.2]hexanes 16 with DIBAL-H. |
