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HOWELL RESEARCH GROUP DEPARTMENT
OF CHEMISTRY |
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New Approaches to 2-Alkylideneoxetanes
Another interest lies in developing straightforward strategies for the
synthesis of 2-alkylidineoxetanes. One strategy involves preparation
of 2-alkylideneoxetanes by the elimination of activated alpha–hydroxyoxetanes
(e.g. the conversion of 30 to 31).
This approach has been successful, and current efforts are directed
to improving the efficiency and to examining stereochemical issues.
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We are
also exploring the use of transition metal-catalyzed alkene isomerization
(double bond migration). |
