HOWELL RESEARCH GROUP

DEPARTMENT OF CHEMISTRY
UNIVERSITY OF CONNECTICUT

PUBLICATIONS

  1. “Synthesis of epi-Oxetin via a Serine Derived 2-Methyleneoxetane,” Blauvelt, M.; Howell, A. R., submitted.

  2. “3-Silyloxytetrahydrofurans via Sulfoxonium Ylide Reactions with a-Silyloxyepoxides,” Sabila, P. S.; Liang, Y.; Howell, A. R. Tetrahedron Lett. in press.

  3. “2-Alkylidene Oxetanes by Stereospecific Elimination of Mesylates,” Sabila, P. S.; Howell, A. R. Tetrahedron Lett. in press.

  4. “Synthesis and Reactions of 2-Alkylidene Thiiranes and Thietanes,” Richardson, S. K.; Howell, A. R. Synthesis, 2007, 2755-2778.

  5. “Rapid Identification of Immunostimulatory a-Galactosylceramides Using Synthetic Combinatorial Libraries,” Li, Q., Ndonye, R. M.; Illarianov, P. A.; Yu, K. O. A.; Jerud, E. S.; Porcelli, S. A.; Besra, G. S.; Chang, Y.-T.; Howell, A. R. J. Combi. Chem. in press.

  6. “Production and characterization of monoclonal antibodies against complexes of the NKT cell ligand a-galactosylceramide bound to mouse CD1d,” Yu, K. O. A.; Im, J. S.; Illarionov, P. A.; Ndonye, R. M.; Howell, A. R.; Besra, G. S.; Porcelli, S. A. J. Immunological Meth. 2007, 323, 11-23.

  7. “Cross Metathesis of a-Methylene Lactones II: g- and d-Lactones,” Raju, R.; Allen, L. J.; Le, T.; Taylor, C. D.; Howell, A. R. Org. Lett. 2007, 9, 1699-1701.

  8. “Improved Outcomes in NOD Mice Treated with a Novel Th2 Cytokine Biasing NKT Cell Activator,” Forestier, C.; Takaki, T.; Molano, A.; Im, J. S.; Blaine, I.; Jerud, E. S.; Illarionov, P.; Ndonye, R.; Howell, A. R.; Santamaria, P.; Besra, G.; DiLorenzo, T. P.; Porcelli, S. A.  J. Immun. 2007, 178, 1415-1425.

  9. “Cross Metathesis with Strained Exocyclic Enones: 3-Alkylideneoxetane-2-ones from 3-Methyleneoxetan-2-ones,” Raju, R.; Howell, A. R. Org. Lett. 2006, 8, 2139-2141.

  10. “T-bet Concomitantly Controls Migration, Survival and Effector Functions During the Development of Va14i NKT Cells,” Matsuda, J. L.; Zhang, Q.; Ndonye, R.; Richardson, S. K.; Howell, A. R.; Gapin, L. Blood 2006, 107, 2797-2805.

  11. “Synthesis and Properties of psico-Nucleosides,” Richardson, S. K.; Howell, A. R.; Taboada, R.  Org. Prep. Proc. Int. 2006, 38, 101-176.

  12. “Synthesis and Evaluation of Sphinganine Analogues of KRN7000 and OCH,” Ndonye, R. M.; Izmirian, D. P.; Dunn, M. F.; Yu, K. O. A.; Porcelli, S. A.; Khurana, A.; Kronenberg, M.; Richardson, S. K.; Howell, A. R. J. Org. Chem. 2005, 70, 10260-10270.

  13. “Multiphoton Excited Fabrication of Collagen Matrices Crosslinked by a Modified Benzophenone Dimer: Bioactivity and Enzymatic Degradation,” Basu, S.; Cunningham, L. P.; Pins, G. D.; Bush, K. A.; Taboada, R.; Howell, A. R.; Wang, J.; Campagnola, P. J. Biomacromolecules, 2005, 6, 1465.

  14. "Approaches to the preparation of sphinganines." Howell, A. R.; So, R. C.; Richardson, S. K. Tetrahedron, 2004, 60, 11327-11347.

  15. "The T cell antigen receptor expressed by Va14i NKT cells has a unique mode of glycosphingolipid antigen recognition." Sidobre, S.; Hammond, K. J. L.; Benazet-Sidobre, L.; Maltsev, S. D.; Richardson, S. K.; Ndonye, R. M.; Howell, A. R.; Sakai, T.; Besra, G. S.; Porcelli, S. A.; Kronenberg, M. Proceedings of the National Academy of Sciences of the United States of America, 2004, 101, 12254-12259.

  16. "Straightforward Synthesis of Sphinganines via a Serine-derived Weinreb Amide." So, R. C.; Ndonye, R.; Izmirian, D. P.; Richardson, S. K.; Guerrera, R. L.; Howell, Amy R. J. Org. Chem., 2004, 69, 3233-3235.

  17. "Unusual, Strained Heterocyles: 3-Alkylidene-2-methyleneoxetanes from Morita-Baylis-Hillman-type Adducts," Martínez, I; Andrews, A. E.; Emch, J. D.; Ndakala, A. J.;Wang, J. Org. Lett., 2003, 5, 399-402.

  18. "Directed Ring-opening of 1,5-Dioxaspiro[3.2]hexanes: Selective Formation of 2,2-Disubstituted Oxetanes," Taboada, R.; Ordonio, G. G.; Ndakala, A. J.; Howell, A. R.; Rablen, P. R. J. Org. Chem., 2003, 68, 1480-1488.

  19. "The Role of Lattice Oxygen in Selective Benzyl Alcohol Oxidation Using OMS-2 Catalyst: A Kinetic and Isotope-Labeling Study, " Makwana, V. D.; Son, Y.-C.; Howell, A. R.; Suib, S. L. Journal of Catalysis  2002,  210,  46-52.

  20. "New Photoactivators for Multi-photon Excited 3 Dimensional Sub-micron Crosslinking of Proteins: Bovine Serum Albumin and Type 1 Collagen," Pitts, J. D. Howell, A. R.; Taboada, R.; Banerjee, I.; Wang, J.; Goodman, S. L.; Campagnola, P. J. Photochemistry and Photobiology, 2002, 76, 135.

  21. "Ring Opening Reactions of 2-Methyleneoxetanes," Wang, Y.; Bekolo, H.; Howell, A. R. Tetrahedron, 2002, 58, 7101.

  22. Synthesis of (D)-erythro-Dihydrosphingosine and (D)-xylo-Phytosphingosine from a Serine-derived 1,5-Dioxaspiro[3.2]hexane Template," Ndakala, A. J.; Hashemzadeh, M.; So, R. C.; Howell, A. R., Org.Lett. 2002, 4, 1719.

  23. "The Preparation and Biological Significance of Phytosphingosines," Howell, A. R.; Ndakala, A. J. Current Organic Chemistry 2002, 6, 365.

  24. "Preparation and Reactions of 4-Oxaspiro[2.3]hexanes," Bekolo, H.; Howell, A. R. New J. Chem. 2001, 25, 673.

  25. "Efficient, Catalytic, Aerobic Oxidation of Alcohols with Octahedral Molecular Sieves," Son, Y.-C.; Makwana, V. D.; Howell, A. R.; Suib, S. L. Angew. Chem. Int. Ed. 2001, 40, 4280.

  26. "The Reaction of Dimethyltitanocene with N-Substituted-beta-Lactams," Martinez, I; Howell, A. R. Tetrahedron Lett. 2000, 41, 5607.

  27. "An Unusual and Efficient Reaction of 2-Methylene-3-phenyloxetane in the Presence of Lithium and DTBB in THF," Hashemzadeh, M.; Howell, A. R. Tetrahedron Lett. 2000, 41, 1859.

  28. “Reductive Cleavage of 2-Methyleneoxetanes with Lithium and 4,4’-di-tert-Butylbiphenyl,” Hashemzadeh, M.; Howell, A. R. Tetrahedron Lett. 2000, 41, 1855.

  29. "3-Dimensional Submicron Polymerization of Acrylamide by Multiphoton Excitation of Xanthene Dyes," Campagnola, P. J.; Delguidice, D. M.; Epling, G. A.; Hoffacker, K. D.; Howell, A. R.; Goodman, S. L. Macromolecules 2000, 33, 1511.

  30. "Preparation and Properties of 2-Methyleneoxetanes," Dollinger L. M.; Ndakala A. J.; Hashemzadeh M.; Wang G.; Wang Y.; Martinez I.; Arcari J. T.; Galluzzo D. J.; Howell, A. R.; Rheingold, A. L.; Figuero, J. S. J. Org. Chem., 1999, 64, 7074.

  31. "Ring-opening of 1,5-Dioxaspiro[3.2]hexanes: Preparation of alpha-Functionalized-beta'-hydroxy Ketones of 2,2-Disubstituted Oxetanes," Ndakala, A. J.; Howell, A. R. Org. Lett. 1999, 1, 825.

  32. "1-Iodomethy-3,4-diphenyl-2,6-dioxabicyclo[2.2.0]hexane: The First Example of a [2.2.0] Fused Ketal," Wang, G.; Wang, Y.; Arcari, J. T.; Howell, A. R.; Rheingold, A. L.; Concolino, T. Tetrahedron Lett. 1999, 40, 7151.

  33. "An Unanticipated Ring-Opening of 2-Methyleneoxetanes: A Fundamentally New Approach to the Preparation of Homopropargylic Alcohols," Dollinger, L. M.; Howell, A. R. J. Org. Chem. 1998, 63, 6782.

  34. "The First General Synthesis of 1,5-Dioxaspiro[3.2]hexanes," Ndakala, A. J.; Howell, A. R. J. Org. Chem. 1998, 63, 6098.

  35. "A 2-Methyleneoxetane Analog of Orlistat Demonstrating Inhibition of Porcine Pancreatic Lipase," Dollinger, L. M.; Howell, A. R. Bioorg. and Med. Chem. Lett. 1998, 8, 977.

  36. "2-Alkylidene Oxetanes: An Investigation of the Paterno-Buchi Reaction between Aliphatic Aldehydes and Allenes," Howell, A. R.; Fan, R.; Truong, A. Tetrahedron Lett. 1996, 37, 8651.

  37. "A Versatile Preparation of 2-Methyleneoxetanes," Dollinger, L. M.; Howell, A. R. J. Org. Chem. 1996, 61, 7248.

  38. "Saturated and Unsaturated Hydrocarbons," Howell, A. R. and Keeling, S. P. in General and Synthetic Methods; Pattenden, G., Ed.; The Royal Society of Chemistry: Cambridge, 1993; Vol. 15, pp 1-31.

  39. "Saturated and Unsaturated Hydrocarbons," Howell, A. R. in General and Synthetic Methods; Pattenden, G., Ed.; The Royal Society of Chemistry: Cambridge, 1992; Vol. 14, pp 1-25.

  40. "Saturated and Unsaturated Hydrocarbons," Howell, A. R. in General and Synthetic Methods; Pattenden, G., Ed.; The Royal Society of Chemistry: Cambridge, 1992; Vol. 13, pp 1-32.

  41. "Synthesis and Binding Activity of 4-Azanicotine Analogues," Smith, W. T.; Howell, A. R.; Martin, W. R.; Sloan, J. W. J. Het. Chem. 1991, 28, 1147.

  42. "Hydrocobaltation Reactions of 1,3-Dienes. Regioselective Hydroxylation of Myrcene to Geraniol and (+)-Linalool via Allylcobaloxime Intermediates," Howell, A. R.; Pattenden, G. J. Chem. Soc. Perkin Trans. I 1990, 2715.

  43. "Cobalt-Mediated Intermolecular Radical Addition to Carbon-to-Carbon Double Bonds Leading to New Functionalized Alkenes," Bhandal, H.; Howell, A. R.; Patel, V. F.; Pattenden, G. J. Chem. Soc. Perkin Trans. I 1990, 2709.

  44. "Regioselective Hydroxylations of 1,3-Dienes via Hydrocobaltation Reactions. Facile Conversion of Myrcene to Geraniol and to (+)-Linalool," Howell, A. R.; Pattenden, G. J. Chem. Soc., Chem. Commun. 1990, 103.

  45. "The Application of Chloromethylaluminum 2-(2-Propenyl)anilide in the Conversion of gamma- and delta-Lactones into Protected Hydroxyacids," Barrett, A. G. M.; Bezhuidenhoudt, B. C. B.; Dhanak, D.; Gasiecki, A. F.; Howell, A. R.; Lee, A.; Russell, M. A. J. Org. Chem. 1989, 54, 3321.

  46. "Redox Glycosidation via Thionoester Intermediates," Barrett, A. G. M.; Bezhuidenhoudt, B. C. B.; Howell, A. R.; Russell, M. A. J. Org. Chem. 1989, 54, 2275.

  47. "Redox Glycosidation: A Novel Approach to Disaccharide Synthesis," Barrett, A. G. M.; Bezhuidenhoudt, B. C. B.; Gasiecki, A. F.; Howell, A. R.; Russell, M. A.; J. Am. Chem. Soc. 1989, 111, 1392.

  48. "Stereospecificity of 2-Methylpiperidine Binding to a Nicotinic Up-Regulatory Site in the Rat Brain P2 Preparation," Sloan, J. W.; Martin, W. R.; Hook, R.; Bostwick, M.; Howell, A. R.; Smith, W. T. Life Sciences 1985, 37, 1367.