EXPERIENCE

1990-             Professor of Clinical Chemistry, University of Connecticut

1976-             Director, Microchemistry Laboratory, University of Connecticut

                     Specialization in bio-analytical methodologies and drug screening procedures.

                     Research Interests:  Development of methods for detection and confirmation of drugs and biotransformation products in biological materials.

1989-             Consultant to Mega Lab, Inc., Bryan, Texas
                     Data interpretation.

1986-1988      Consultant to Waters Associates, Milford, MA
                     Development of computer search routine for HPLC/UV analysis of drugs.

1985-             Consultant, Department of Pathology, Hartford Hospital, Hartford, CT
                     Advise staff on methods and regulations to establish drug screening program.

1983-1990      Associate Professor of Clinical Chemistry, University of Connecticut

1983-             Joint Appointment to School of Pharmacy, University of Connecticut

1982-1985      Consultant to Waters Associates, Milford, MA
                     Development of HPLC methods for analyzing amino acids.

1976-1982      Assistant Professor of Clinical Chemistry, University of Connecticut

1972-1976      Graduate Assistant, Department of Biochemistry and Biophysics, Texas A&M University
 

EDUCATION

1976              Ph.D., Biochemistry, Texas A&M University

1972              B.S., Biology, Midwestern University
 

PROFESSIONAL ORGANIZATIONS

Association of Official Racing Chemists
American Association for Clinical Chemistry
 

PUBLICATIONS

Dolan, J.W., Snyder, L.R., Djordjevic, N.M., Hill, D.W. and Waeghe, T.J.,  "Reversed-phase liquid chromatographic separation of complex samples by optimizing temperature and gradient time  II.  Two-run assay procedures", J. Chromatogr. A, Vol. 857, 21-39 (1999)

Dolan, J.W., Snyder, L.R., Djordjevic, N.M., Hill, D.W. and Waeghe, T.J.,  "Reversed-phase liquid chromatographic separation of complex samples by optimizing temperature and gradient time I. Peak capacity limitations",  J. Chromatogr. A, Vol. 857, 1-20 (1999)

Court, M.H., Hay-Kraus, B.L., Hill, D.W., Kind, A.J. and Greenblatt, D.J., "Propofol hydroxylation by dog liver microsomes:  Assay development and dog breed differences",  Drug Metabolism and Disposition. Vol. 27(11), 1293-1299 (1999)

Wu, A.H.B., Briston,B., Sexton, K., Cassella-McLane, G., Holtman, V. and Hill, D.W.,  "Adulteration of Urine by "Urine Luck", Clin. Chem. Vol. 45(7), 1051-1057 (1999)

Wu, A.H.B., Hill, D.W., Crouch, D., Hodnett, C.N. and McCurdy, H.H., "Minimal Standards for the Performance and Interpretation of Toxicology:  Tests in Legal Cases.", J. Forensic Sci., Vol. 44(3), 516-522 (1999)

Williams, Tracy M., Kind, A.J., Houghton, E. and Hill, D.W.,  "Electrospray Collision- induced Dissociation of Testosterone and Testosterone analogs.",  J. Mass Spectrom. Vol 34(3), 206-216 (1999)

Cremese, M., Wu, A.H.B., Cassella, G., OíConnor, E., Rymut, K. and Hill, D.W.,  "Improved GC/MS Analysis of Opiates with use of Oxime-TMS Derivatives.", J. Forensic Sci., Vol. 43(6), 1220-1224 (1998)

Brady, T.C., Kind, A.J., Hyde, W., Favrow, M.. and Hill, D.W.  "Isolation, Purification and Structural Characterization of Flunixin Glucuronide in the Urine of Greyhound Dogs.". Drug Metabolism and Disposition, Vol. 26(4), 294-298 (1998)

Jensen, R.G., Lammi-Keefe, C.J., Hill, D.W., Kind, A.J. & Henderson, R., "The Anticarcinogenic Conjugated Fatty Acid, 9c, 11t-18:2, in Human Milk:  Confirmation of Its Presence",  J. Hum. Lact. 14(1), 23-27, (1998)

Dolan, J.W., Snyder, L.R., Djordjevic, N.M., Hill, D.E., Saunders, D.L., VanHeukelem, L. and Waeghe, T.J.,  "Simultaneous variation of temperature and gradient steepness for reversed-phase high-performance liquid chromatography method development.  I.  Application to 14 different samples using computer simulation."
 J. Chromatogr. A, 803, 1-31, (1998)

Hill, D.W., Kind, A.J. and Hyde, W., "HPLC Positive Ion Electrospray Analysis of Dexamethasone in Greyhound Urine",  Proceedings of the 50th Meeting of the Association of Official Racing Chemists, Boston, (1997)

Cassella, Gina, Wu, A.H.B., Shaw, B. and Hill, D.W.,  "The Analysis of Thebaine in Urine for the Detection of Poppy Seed Consumption"  J. Anal. Tox., 21(5), 376-383, (1997)

Brady, T.C., Kind, A.J., Yang, T.J., Hyde, W. and Hill, D.W.,  "Detection of Flunixin in Greyhound Urine by a Kinetic Enzyme-linked Immunosorbent Assay".  J. Anal. Tox.  Vol. 21(3), 190-196 (1997)

Ostheimer, D., Cremese, M., Wu, A.H.B. and Hill, D.,  "Reduction in Extraction Efficiency of Charged Particles from the Ion Source as the Cause of Matrix Effects in the Gc-MS Analysis of Drugs",  J. Anal. Tox.  Vol. 21(1), 17-22 (1997)

Zhu, P.L., Snyder, L.R., Dolan, J.W., Kjordjevic, N.M., Hill, D.W., Sander, L.C. and Waighe, T.J.,  "Combined Use of Temperature and Solvent Strength in Reversed-phase Gradient Elution.  I.  Predicting Separation as a Function of Temperature and Gradient Conditions",  J. Chromatogr. A. Vol. 756, p.21 (1996)

Zhu, P.L., Dolan, J.W., Snyder, L.R., Hill, D.W., Van Heukelem, L. and Waighe, T.J.,  "Combined Use of Temperature and Solvent Strength in Reversed-phase Gradient Elution.  III.  Selectivity for Ionizable Samples as a Function of Sample Type and Other Separation Conditions", J. Chromatogr. A. Vol. 756, p.51 (1996)

Zhu, P.L., Dolan, J.W., Snyder, L.R., Kjordjevic, N.M., Hill, D.W., Lin, J.T., Sander, L.C., and Van Heukelem, L., "Combined Use of Temperature and Solvent Strength in Reversed-phase Gradient Elution.  IV.  Selectivity for Neutral (non-ionized) Samples as a Function of Sample Type and Other Separation Conditions", J. Chromatogr. A. Vol. 756, p.71 (1996)

Williams, T.M., Kind, A.J., Yang, T.J., Hyde, W. and Hill, D.W., "In Vitro Biotransformation Studies of Anabolic Steroids using Electrospray Mass Spectrometry for Structural Elucidation",  Proc. 11th Intl. Conf. Racing Analysts and Veterinarians,  Australia (1996)

Bogusz, M., Hill, D.W. and Rehorek, A.,  "Comparability of RP-HPLC Retention Indices of Drugs in Three Databases",  J. Liq. Chrom. & Rel. Technol., 19(8), 1291-1316 (1996)

Palaniswamy, U., McAvoy, R., Bible, B., Singha, S. and Hill, D.  "Phenylethyl Isothiocyanate Concentration in Watercress (Nasturtium officinale R.Br.) is Altered by the Nitrogen to Sulfur Ratio in Hydroponic Solution",  Proceedings 10th Annual Penn State Symposium in Plant Physiology, 280-283, (1995)

Palaniswamy, U., McAvoy, R.J., Bible, B., Singha, S. and Hill, D.  "Effect of different nitrogen-sulfur ratios on 2-Phenylethyl isothiocyanate (PEITC) levels in watercress."  Hort. Science, 30:789 (1995)

Wu, Alan H.B., Timothy Kelly, Charles McKay, Donna Ostheimer, Elaine Forte, and Dennis Hill, "Definitive Identification of an Exceptionally High Methanol Concentration in an Intoxication of a Surviving Infant:  Methanol Metabolism by First-Order Elimination Kinetics", JFSCA 40(2), 315-320 (1995)

Hill, Dennis W., T.C. Brady, A. J. Kind, T. J. Yang and W. G. Hyde,  "Detection and Confirmation of Flunixin in Greyhound Urine".  Proc. 10th Intl. Conf. Racing Analysts and Veterinarians, Stockholm, Sweden (1994)

Kind, Albert J., Dennis W. Hill and Walter Hyde,  "Analysis of Flumethasone in Greyhound Urine by HPLC Electrospray Mass Spectrometry",  Proceedings of the 48th Meeting of the Association of Official Racing Chemists, 1995.

Hill, Dennis, W., Albert J. Kind and Walter Hyde,  "Biotransformation and Urinary Excretion Profile of Nikethamide in the Greyhound Dog",  Proceedings of the 48th Meeting of the Association of Official Racing Chemists, 1995.

Wu, Alan H.B., Donna Ostheimer, Michael Cremese, Elaine Forte, and Dennis Hill, "Characterization of Drug Interferences Caused by Coelution of Substances in Gas Chromatography/Mass Spectrometry Confirmation of Targeted Drugs in Full-Scan and Selected-Ion Monitoring Modes", Clin. Chem. 40(2), 216-220 (1994).

Hill, Dennis W. and Albert J. Kind, "Reversed-Phase Solvent-Gradient HPLC Retention Indexes of Drugs", J. Anal. Tox. Vol. 18, 233-242 (1994).

Hill, Dennis W. and Albert J. Kind, "The Effects of Type B Silica and Triethylamine on the Retention of Drugs in Silica Based Reverse Phase High Performance Chromatography", J. Liq. Chromatogr., 16(18), 3941-3964 (1993).

Hill, Dennis W. and Albert J. Kind, "Automated HPLC/Diode Array UV Spectral Drug Screening", Proceedings of the Association of Racing Chemists, April,1993, New York City.

Hill, Dennis W., Evaluationof Alkyl Bonded Silica and Solvent Phase Modifiers for the Efficient Elution of Basic Drugs on HPLC., J. Liq. Chromatogr., 13(16), 3147-3175 (1990).

Hill, Dennis W. and Langner, Karen J., Screening with High Performance Liquid Chromatography,  Analytical Aspects of Drug Testing, ed.  Dale Deutsch, John Wiley & Sons Publishers, (1989).

Kind, A.J., Hill, D.W. and Hyde, W., Metabolism of Fenbendazole and Mebendazole in the Dog., Proceedings of the Seventh International Conference of Racing Analysts and Veterinarians, (1988).

Hill, Dennis, W., HPLC/Diode Array Analysis of Drugs in the Urine of Greyhound Dogs and Jai Alai Players.  Proceedings of the 54th Annual Convention of the National Association of State Racing Commissioners, (1988).

Camp, B.J., Bridges, C.H., Hill, D.W., Patamalai, B. and Wilson, S.,  Isolation of a Steroidal Sapogenin from the Bile of a Sheep Fed Agave Lechequilla.  Vet. and Human Tox.
 Vol. 30, No. 6, 533-535 (1988).

Clark, R.M., Ross, S.A., Hill, D.W. and Ferris, A.M., Within-Day Variation of Taurine and Other Nitrogen Substances in Human Milk.  J. Dairy Sci., Vol. 70, 776-780 (1987).

Hill, D.W. and Langner, K.J.,  HPLC Photodiode Array UV Detection for Toxicological Drug Analysis.  J. Liq. Chromatogr., 10(1&2), 377-409 (1987).

Hill, D.W., Kelley, T.R. and Langner, K.J.,  Computerized Library Search Routine for Comparing Ultraviolet Spectra of Drugs Separated by High Performance Liquid Chromatography.  Anal. Chem., 59, 350-353 (1987).

Hyams, J.S., Leichtner, A.M., Breiner, R.G., Hill, D.W., McComb, R.B. and Manager, W.M.,  Pseudopheochromocytoma and Cardiac Arrest Associated with Phenylpropanolamine.  JAMA, 253(11), 1609-1610 (1985).

Hill, D.W., Kelley, T.R., Langner, K.J. and Miller, K.W.,  Determination of Mycotoxins by Gradient High Performance Liquid Chromatography Using an Alkylphenone Retention Index System.  Anal. Chem., Vol. 56, 2576-2579 (1984).

 Eslami, M., Stuart, J.D. and Hill, D.W.,  Separation of Orthophthaladehyde/Ethanethiol Derivatives of Taurine and Closely Eluting Amino Acids by High Performance Liquid Chromatography.  J. Liq. Chromatogr., 7(6), 1117-1131 (1984).

Samples, D., Hill, D.W., Bridges, C.H. and Camp, B.J.,  Isolation of a Mycotoxin (Roridin A) from Phomopsis spp.  Vet. and Human Tox., Vol. 26, No. 21, 21-23 (1984).

Sundlof, S.F., Duer, W.C., Hill, D.W., Gancarz, T., Dorvil, M.G. and Rosen, P.,  Procaine in the Urine of Greyhounds:  Possible Sources.  Am. J. Vet. Res., Vol. 44, No. 8, 1583-1587 (1983).

Clark, R.M., Fey, M.B., Jensen, R.G. and Hill, D.W.,  Demosterol in Human Milk.  Lipids, Vol. 18, No. 3, 264-266 (1983).

Stuart, J.D. and Hill, D.W.,  Liquid Chromatographic Determination of Taurine,  Handbook of HPLC for the Separation of Amino Acids, Peptides and Proteins. ed., W. D. Hancock,  CRC Press, Inc., Boca Raton, FL (1983).

Hill, D.W., Brande, W., Phillips, D. and Pomerleau, O.,  A Rapid Plasma Extraction Method for Gas Chromatographic Analysis of Nicotine.  Anal. Letters, 16(B5), 355-365 (1983).

Pfeifer, R.F. and Hill, D.W.,  High Performance Liquid Chromatography of Amino Acids:  Ion-Exchange and Reversed-Phase Strategies,  Advances in Chromatography.  Vol. 22., Chapter 2.  Marcel Dekker, Inc., New York (1983).

Bailie, A.G. Jr., Wilson, T.D., O'Brien, R.K., Beebe, J.M., Stuart, J.D., McCosh-Lilie, E.J. and Hill, D.W.,  High Performance Liquid Chromatography Analysis of Underivatized Fatty Acids in Margarines.  J. of Chromatographic Sci., Vol. 20, 466-470 (1982).

Hill, D.W., Burnworth, L., Skea, W. and Pfeifer, R.,  Quantitative HPLC Analysis of Plasma Amino Acids as Orthophthaldialdehyde/Ethanethiol Derivatives.  J. Liq. Chromatogr.  5(12), 2369-2393 (1982).

Hill, D.W., Kelley, T.R., Matiuck, S.W., Langner, K.J. and Phillips, D.E.,  Single Extraction for the Recovery of Basic, Neutral and Weakly Acidic Drugs from Greyhound Dog Urine. Anal. Letters, 15(B2), 193-204 (1982).

Hill, D.W., Kelley, T.R., Morrow, G.R. and Langner, K.J.,  Metals in Honey Produced and Marketed in Connecticut.  Storrs Agricultural Experiment Station, CANR, University of Connecticut, Res. Report 68 (1981).

Hill, D.W., Bailey, E.M. and Camp, B.J.,  Tissue Distribution and Disposition of Hymenoxon.  J. Agric. Food Chemistry, Vol. 28, No. 6, 1269-1273 (1980).

Hill, D.W., Walters, F.H., Wilson, T.D. and Stuart, J.D.,  High Performance Liquid Chromatographic Determination of Amino Acids in the Picomole Range.  Anal. Chem., Vol. 51, 1338-1341 (1979).

Hill, D.W. and Camp, B.J.,  Reactions of Hymenoxon:  Base Conversion to Psilotropin and Greenein and Formation of 'Michael Adduct' with Cysteine.  J. Agric. Food CHemistry, Vol. 27, No. 4, 882-884 (1979).

Stuart, J.D., Wilson, T.D., Hill, D.W., Walters, F.H. and Feng, S.Y.,  High Performance Liquid Chromatographic Separation and Fluorescent Measurement of Taurine, A Key Amino Acid.  J. Liquid. Chromatogr.  2(6), 809-821 (1979).

Hill, D.W., Kim, H. L. and Camp, B.J.,  Quantitative Analysis of Hymenoxon in Plant Tissue.  J. Agric. Food Chemistry, Vol. 27, No. 4, 885-887 (1979).

Hill, D.W., Kelley, T.R., Morrow, G.R., and Matiuck, S.W.,  Metals in Apple Cider Produced and Marketed in Connecticut.  Storrs, Agricultural Experiment Station, CANR, University of Connecticut,  Res. Report 57 (1979).

Hill, D.W., Kim, H.L., Martin, C.L. and Camp, B.J.  Hymenoxon in Baileya multiradiata and Helenium hoopsi.  Agricultural and Food Chemistry, Vol. 25, No. 6, 1304-1307 (1977).

Hill, D.W., Hejtmancik, E. and Camp, B.J.  Induction of Hepatic Microsomal Enzymes by Aroclor in Ictalurus punctatus (Channel Catfish).  Bull. of Environmental Contamination & Toxicology, Vol. 16, No. 4, 495-502 (1976).

RECENT ABSTRACTS

Dolan, J.W., Snyder, L.R., Kjordjevic, N.M., Hill, D.W., VanHeukelem, L. and Waeghe, T.J., "Multi-run Procedures for the Separation and Analysis of Complex Samples by Means of Reversed-Phase Gradient Elution:,  Presented at LC-98 Meeting in St. Louis, May, 1998.

Williams, T.M. and Hill, D.W.,  "Testosterone and Boldenone Metabolites Generated by Dog Liver Microsomes:  Synthesis and Isolation.  F.A.S.E.B. 10(3), 1996.

Williams, T.M. and Hill, D.W.,  "Testosterone and Boldenone Metabolites Generated by Dog Liver Microsomes:  Synthesis and Isolation.  35th Annual Meeting, Society of Toxicology, Anaheim, CA, March, 1996

Williams, T.M. and Hill, D.W.,  "Testosterone and Boldenone Metabolites Generated by Dog Liver Microsomes:  Synthesis and Isolation.  25th New England Pharmacologists Annual Meeting, Boxborough, MA, February, 1996

Wu, Alan H.B., Ostheimer, Donna, Forte, Elaine, McKay, Charles, Kelly, Tim and Hill, Dennis W., "Survival of an Infant with an Exceptionally High Serum Methanol Concentration:  Presentation of First-order Elimination Kinetics.", Clin. Chem.  41(6), S117, 1995

Ostheimer, Donna, Cremese, M., Wu, A. and Hill, D., "Reduction in Extraction Efficiency of Charged Particles from the Ion Source as the Cause of Matrix Effects in the GC/MS Analysis of Drugs.", Clin. Chem.  41(6), S129, 1995

Huang, J.C., Sulkowski, H., Hill, D. and Wu, A.H.B., "Michaelis-Menten Kinetics for Alcohol Dehydrogenase and Catalase.", Clin. Chem.  41(6), S234, 1995

Williams, T.M. and Hill, D.W.,  "Testosterone and Boldenone Metabolites Generated by Dog Liver Microsomes:  Synthesis and Isolation. Northeast Chapter Society of Toxicology, Sturbridge, MA, October, 1995

Williams, T. M. and Hill, D. W., "Testosterone Biotransformation by Rat Liver microsomes:  Detection of Various Metabolites by Reverse-Phase High Performance Liquid Chormatography (HPLC)", Toxicologist 15(1), 261, 1995

Ostheimer, D., OíConnor, E., Wu, A. and Hill, D.W.  "Evaluation of a Commercial ELISA Assay for Meperidine in Urine."  Clin. Chem. 40(6), 1994

Anderson, D., M. Cremese, E. Forte, A. Wu, and D. Hill, "False Negative Results for Benzoylecgonine in Urine using Gc/MS Analysis Due to Fluconazole", Clin. Chem. 39(6), 1233 (1993).

Anderson, D. and D.W. Hill, "Evaluation of SYVA EMIT and Abbott TDx Serum Tricyclic Anti-depressant Toxicology Assays for the Analysis of Tricyclic Anti-depressants in Urine Samples",  Regional AACC Meeting, October, 1992, Tarreytown, New York

Anderson, D., E. Forte, G. Hodilewsky, G. Bowers, Jr., D.W. Hill,  "Experience with SYVA EMIT DAU Monoclonal Amphetamine/Amphetamine Assay in Medical Drug Screening",  Clin. Chem., 38(6), 994 (1992).
 

Updated 11/9/99